Torna ai risultati della ricercaBando per assegno di ricerca
| Titolo del progetto di ricerca in italiano | IDENTIFICATION OF NEW POTENTIALLY ACTIONABLE ALTERATIONS IN PANCREATIC DUCTAL ADENOCARCINOMA BY NEXT GENERATION SEQUENCING |
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| Titolo del progetto di ricerca in inglese | IDENTIFICATION OF NEW POTENTIALLY ACTIONABLE ALTERATIONS IN PANCREATIC DUCTAL ADENOCARCINOMA BY NEXT GENERATION SEQUENCING |
| Campo principale della ricerca | Biological sciences |
| Sottocampo della ricerca | Biology |
| Settore Concorsuale | 05 - Scienze biologiche |
| S.S.D | - |
| Descrizione sintetica in italiano | The sequencing data will be produced on the Illumina HiScanSQ platform by whole exome sequencing at 100 bp in paired end. the reads obtained will be mapped on Human reference Genome (hg19) with Burrows-Wheeler Aligner after quality control, adapter removal and trimming of low quality bases. Alignment data will be processed with Samtools to perform PCR duplicate elimination and with GATK to realign around insertion/deletion (InDel) position and recalibration of quality. The same software GATK will be adopted to detect the InDel (HaplotypeCaller function), while single nuceotide variants (SNVs) will be identified with MuTect. The variants called will be annotated with Annovar and filtrated based on depth of coverage, ratio of altered base, presence on data bank of human variability (dbSNP, |
| Descrizione sintetica in inglese | PDA is the fourth leading cause of cancer death, with a 5-years .Surgery remains the most effective treatment, but only 20% of patients are suitable for radical resection. Advances in chemotherapy, have resulted in a modest outcome improvement . Despite a limited impact on patient care, in the last years the genomic characterization of PDA has advanced substantially , inducing to consider PDA not only as a collection of pancreatic cancer cells but a complex organ composed of several components each of equal importance for tumor carcinogenesis, growth and maintenance. In particular, the stromal microenvironment was found to be the main dynamic compartment, enabling tumor growth and development as well as the role of pancreatic stem cells in carcinogenesis is already established. Next-generation sequencing further clarified the genomic complexity of PDA through the molecular dissection of all the somatic alterations generating a lots of new informative data on cancers |
| Data del bando | 08/09/2015 |
| Paesi in cui può essere condotta la ricerca |
Italy |
| Paesi di residenza dei candidati |
All |
| Nazionalità dei candidati |
All |
| Sito web del bando | https://www.aricweb.unibo.it/BandiPubblicati/zz_Bandi_din.aspx |
| Destinatari dell'assegno di ricerca (of target group) |
Early stage researcher or 0-4 yrs (Post graduate) |
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| Criteri di selezione in italiano (breve descrizione) | il bando e la modulistica per partecipare alla procedura di valutazione comparativa sono disponibili all'indirizzo: https://www.aricweb.unibo.it/BandiPubblicati/zz_Bandi_din.aspx |
| Criteri di selezione in inglese (breve descrizione) | to apply for research grants fill out the form available at the following address: https://www.aricweb.unibo.it/BandiPubblicati/zz_Bandi_din.aspx |
| Nome dell'Ente finanziatore | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - CENTRO INTERDIPARTIMENTALE DI RICERCHE SUL CANCRO "GIORGIO PRODI" (CIRC) |
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| Tipologia dell'Ente | Public research |
| Paese dell'Ente | Italy |
| Città | Bologna |
| Sito web | http://www.unibo.it |
| ciro.danzo@unibo.it |
| L'assegno finanziato/cofinanziato attraverso un EU Research Framework Programme? | No |
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| Data di scadenza del bando | 22/09/2015 - alle ore 00:00 |
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| Come candidarsi | Other |