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| Titolo del progetto di ricerca in italiano | The role of ALK (Anaplastic Lymphoma Kinase) in the DNA repair system |
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| Titolo del progetto di ricerca in inglese | The role of ALK (Anaplastic Lymphoma Kinase) in the DNA repair system |
| Settore Concorsuale | 05 - Scienze biologiche |
| S.S.D | - |
| Descrizione sintetica in italiano | Normal/immune cell interactions are critical for several pathogenetic mechanisms. The full lists of genomic loci, mutations, and epigenetic alterations affecting immunotherapies are not yet known. Immunotherapy is highly effective in immunologically 'hot' tumors; however, new personalized chemo-immune combinations must be developed to treat unresponsive tumors. This task aims to validate at the single-cell level the role of ALK (Anaplastic Lymphoma Kinase) in the DNA damage response system, in order to select patients who could benefit from combinatorial therapy for preventing disease progression. In particular, ALK overexpressing cells will be characterized in 3D in vitro functional preclinical models, including both spheroids and organoids. The DNA damage, along with phenotypical features, will be analyzed under ALK overexpression and targeting by TKI. |
| Descrizione sintetica in inglese | Normal/immune cell interactions are critical for several pathogenetic mechanisms. The full lists of genomic loci, mutations, and epigenetic alterations affecting immunotherapies are not yet known. Immunotherapy is highly effective in immunologically 'hot' tumors; however, new personalized chemo-immune combinations must be developed to treat unresponsive tumors. This task aims to validate at the single-cell level the role of ALK (Anaplastic Lymphoma Kinase) in the DNA damage response system, in order to select patients who could benefit from combinatorial therapy for preventing disease progression. In particular, ALK overexpressing cells will be characterized in 3D in vitro functional preclinical models, including both spheroids and organoids. The DNA damage, along with phenotypical features, will be analyzed under ALK overexpression and targeting by TKI. |
| Data del bando | 09/09/2024 |
| Paesi in cui può essere condotta la ricerca |
Italy |
| Paesi di residenza dei candidati |
All |
| Nazionalità dei candidati |
All |
| Sito web del bando | https://bandi.unibo.it/ricerca/assegni-ricerca |
| Destinatari dell'assegno di ricerca (of target group) |
Early stage researcher or 0-4 yrs (Post graduate) |
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| Criteri di selezione in italiano (breve descrizione) | il bando e la modulistica per partecipare alla procedura di valutazione comparativa sono disponibili all'indirizzo: https://bandi.unibo.it/ricerca/assegni-ricerca |
| Criteri di selezione in inglese (breve descrizione) | to apply for research grants fill out the form available at the following address: https://bandi.unibo.it/ricerca/assegni-ricerca |
| Nome dell'Ente finanziatore | ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA - - DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE |
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| Tipologia dell'Ente | Public research |
| Paese dell'Ente | Italy |
| Città | Bologna |
| Sito web | http://www.unibo.it |
| sam.nonstrutturati@unibo.it |
| L'assegno finanziato/cofinanziato attraverso un EU Research Framework Programme? | No |
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| Data di scadenza del bando | 24/09/2024 - alle ore 23:59 |
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| Come candidarsi | Other |